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Sarah Arcos
I am passionate about using computational methods to explore high-throughput biological datasets in a reproducible and rigorous way. I am a post-doctoral fellow in Dr. Adam Lauring’s lab at the University of Michigan, where I use molecular biology, computational, and statistical toolboxes to study RNA virus evolution.
Education
PhD., Biochemistry
Vanderbilt University
Nashville, TN
2020 - 2015
- Studying RNA-protein interactions and RNA virus replication
B.S., Neurobiology, Cum laude
Georgetown University
Washington, DC
2015 - 2011
- Studied developmental biology of the central nervous system
Research Experience
Postdoctoral Fellow
Lauring Laboratory
University of Michigan
Current - 2021
- RNA virus evolution
- Influenza A polymerase speed and fidelity
- Epistatic interactions within the Influenza A polymerase complex
Graduate Researcher
Ascano Laboratory
Vanderbilt University
2020 - 2015
- RNA virus replication, innate immune evasion
- Protein-RNA interactions
- Post-transcriptional gene regulation in the innate immune system
HHMI Undergraduate Research Assistant
Silva Laboratory
Georgetown University
2015 - 2012
- Investigated the role and regulation of SOX14 during central nervous system development
- Used the model organism Xenopus laevis
Industry Experience
Infectious Disease/Microbiology Intern
Advisors: Dr. Bret Sellman, Dr. Taylor Cohen
MedImmune/Astra Zeneca
2018 - 2018
- Antibody design and development
- mtDNA haplogroup-dependent neutrophil responses to Staphylococcus aureus alpha-toxin
- Neutrophil extracellular trap release
Teaching Experience
I believe that scientific reproducibility depends upon improved communication between data producers and data analyzers, and I am passionate about increasing data analysis accessibility for wet lab biologists.
R Fridays Founder
Vanderbilt Biochemistry Department
Vanderbilt University
Current - 2019
- Leader of a peer group dedicated to discussion and problem solving related to biological data analysis in R
- The R fridays blog is updated with interesting discussion topics from previous meetings
Software Carpentries Instructor
Michigan Medicine
University of Michigan
Current - 2023
- Instructor and TA for UM Software Carpentries Workshops
- TA: March 28th - 29th, 2023
- Instructor: May 14th - 25th, 2023
Service Positions
Vice President, Biochemistry Student’s Association
N/A
Vanderbilt University
2018 - 2017
- Coordinated the 2018 Biochemistry Department Annual Symposium
Selected Press (About)
Selected Press (By)
Dr. David Mitchell2
RNA Society
N/A
2019
- Authored a spotlight on fellow RNA Society member Dr. David Mitchell
Publications
Mutual information networks reveal evolutionary relationships within the Influenza A polymerase3
Virus Evolution
N/A
2023
- Sarah Arcos, Alvin X. Han, Aartjan J W Te Velthuis, Colin A Russell, and Adam S Lauring
ELAVL1 primarily couples mRNA stability with the 3’ UTRs of interferon stimulated genes4
Cell Reports
N/A
2021
- Katie Rothamel, Sarah Arcos, Byungil Kim, Clara Reasoner, Neelanjan Mukherjee, and Manuel Ascano
Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV using VIR-CLASP
Molecular Cell
N/A
2020
- Byungil Kim*, Sarah Arcos*, Katherine Rothamel, Jeffrey Jian, Kristie L Rose, W Hayes McDonald, Yuqi Bian, Seth Reasoner, Nicholas J Barrows, Shelton Bradrick, Mariano A Garcia-Blanco, and Manuel Ascano. *Co-first authors
Selected Talks
Mutual information networks reveal evolutionary relationships within the Influenza A polymerase
FASEB Mechansisms of Microbial Pathogenesis Meeting
Southbridge, MA
2023
Mutual information networks reveal evolutionary relationships within the Influenza A polymerase
American Society for Virology Annual Meeting
Madison, WI
2022
Discovery of widespread host protein interactions with pre-replicated RNA virus genomes using VIR-CLASP
EMBL Protein Synthesis and Translational Control Workshop
Heidelberg, Germany
2019
N6-Methyladenosine-dependent regulation of RNA during Chikungunya virus infection
RNA Society Annual Meeting
Berkeley, CA
2018
The role and regulation of SOX14 in the development of the central nervous system in Xenopus laevis
Georgetown- Howard Hughes Medical Institute Summer Research Symposium
Washington, DC
2014
Grants and Awards
Molecular Mechanisms of Microbial Pathogenesis Post-doctoral Training Grant
University of Michigan
N/A
2022 - 2021
- T32AI007528, PI: Dr. Vern Carruthers
Vanderbilt Russell G. Hamilton Graduate Leadership Institute Travel Grant
Vanderbilt University
N/A
2020
- Used to attend rstudio::conf 2020 in San Francisco, CA
EMBL Advanced Training Center Corporate Partnership Travel Fellowship
EMBL Heidelberg
N/A
2019
- Used to attend the 2019 EMBL Protein Synthesis and Translational Control Workshop
National Institute of Allergy and Infectious Diseases Pre-doctoral Training Grant
Vanderbilt University
N/A
2018 - 2016
- T32AI11254, PI: Dr. Eric Skaar
RNA Society Travel Grant
RNA Society
N/A
2018
- Used to attend the 2018 RNA Society Annual Meeting in Berkeley, CA
Frank Chytil Travel Award
Vanderbilt University
N/A
2018
- Used to attend the 2018 RNA Society Annual Meeting in Berkeley, CA
Best Poster Award, Vanderbilt Biochemistry Department Annual Symposium
Vanderbilt University
N/A
2018
- Poster title: N6-Methyladenosine-dependent regulation of RNA during Chikungunya virus infection and innate immune activation
Professional Memberships
American Society for Virology
N/A
N/A
Current - 2021
RNA Society
N/A
N/A
2021 - 2018
Biochemistry Students Association
Vanderbilt University
N/A
2020 - 2016
Vanderbilt Institute of Chemical Biology
Vanderbilt University
N/A
2020 - 2016
Chemical Biology Association of Students
Vanderbilt University
N/A
2020 - 2016
Links
- https://news.vumc.org/2020/05/07/new-method-captures-early-viral-host-protein-interactions/
- https://www.rnasociety.org/dr--david-mitchell
- https://academic.oup.com/ve/article/9/1/vead037/7181271
- https://www.biorxiv.org/content/10.1101/2020.08.24.263418v1
- https://www.biorxiv.org/content/10.1101/2020.04.08.032441v1